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. 2020 May 13;8:460. doi: 10.3389/fbioe.2020.00460

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Copyright © 2020 Guo, Wang, Gao, Li, Hao, Ning and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TF-lncRNA regulatory cliques are associated with cancer hallmarks. (A) Clustering profile of the top 50 cliques based on their similarity. (B) Different clusters of cliques were associated with a broad range of cancer hallmarks. (C) The hazard ratio and 95% confidence interval for each of the 50 TF-lncRNA cliques based on Cox regression analysis. Most of the cliques (48 of 50) were significantly associated with patient prognosis (P < 0.05). *P < 0.05, **P < 0.01, and ***P < 0.001. (D) A world cloud map indicating TF frequency in the 50 cliques. Some well-known cancer prognostic genes such as STAT3, ETS1, and FOS were frequently involved in different cliques.