Why carry out this study?

Rates of blood pressure control among overweight and obese individuals are often suboptimal due to specific pathogenetic mechanisms and additional comorbidities and risk factors.

A post hoc analysis of the observational FORSAGE study was conducted to assess the effectiveness of switching patients on previous antihypertensive therapy to a perindopril arginine/indapamide (10 mg/2.5 mg) single-pill combination with regard to baseline body mass index (BMI).

What was learned from the study?

High rates of target blood pressure achievement were observed in all BMI groups including the overweight and obese.

The mechanisms of action of perindopril and indapamide may make them particularly suitable for use in obesity-associated hypertension.