ATTR-CM remains a highly elusive and life-threatening diagnosis.

Numerous clinical scenarios with both cardiac and extra-cardiac manifestations can serve as screening tools for clinicians.

Definitive diagnosis of ATTR-CM can now be made noninvasively with newer imaging techniques.

Cardiac scintigraphy remains an indispensable imaging modality in the diagnosis of ATTR-CM.

A positive cardiac scintigraphy scan does not differentiate ATTR-CM from AL-amyloid CM, therefore a thorough multidisciplinary evaluation is still required.