HIV treatment has evolved from a time where two-drug regimens (2DRs) were once considered a novel concept to current times where they are a reality.

Over the past year, national guidelines recommend 2DRs for initial consideration in the management of HIV for patients meeting certain criteria.

When compared with three-drug regimens, many 2DRs have demonstrated noninferiority, in terms of virologic efficacy, in both the treatment-naïve and -experienced populations.