Figure 2.

Estimates of amikacin clearance (L/h) trends in early neonatal life based on pooling of reported datasets (dashed lines). There is a maturational trend in clearance related to birth weight (g) and postnatal age (PNA, days 1,2,3,4, as reflected by the colors) compared to a subgroup of term neonates undergoing therapeutic hypothermia as treatment for perinatal asphyxia (solid lines) (Cristea et al., 2017). The arrows indicate the difference in clearance between both cohorts for the respective PNA. Adapted from De Cock et al., antibiotic dosing in pediatric critically ill patients, Chapter in Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill, Springer Nature Signapore 2018:239–263, with permission from Springer Nature (De Cock et al., 2018).