Table 4.
Dependencies among CES-D score, metabolites, and covariates based on HSIC statistics.
| Response variable | Metabolites selected in both nonlinear and linear models | Metabolites selected only in linear models | Metabolite selected only by P values from multiple regression | |||
|---|---|---|---|---|---|---|
| CES-D score | 3-Hydroxyisobutyrate | Gamma-linolenyl carnitine | l-Leucine | Uric acid | l-gamma-glutamyl-l-leucine | |
| NMR | MS C18 | MS C18 | MS C18 | MS C18 | ||
| Covariates | ||||||
| Sex | 0.9 | 5.6 | 0.7 | 15.7 | 29.5 | 15.8 |
| Age | 1.0 | 1.3 | 1.5 | 1.5 | 1.7 | 3.0 |
| BMI | 1.0 | 2.3 | 0.3 | 3.6 | 4.7 | 2.8 |
| Marital status | 0.6 | 0.1 | 0.5 | 0.2 | 0.1 | 0.3 |
| Damage from the Great East Japan Earthquake | 0.9 | 0.5 | 0.1 | 0.6 | 0.5 | 0.5 |
| Antidepressants | 0.4 | 0.3 | 0.1 | 0.2 | 0.0 | 0.1 |
| LSNS-6 | 1.6 | 0.2 | 0.2 | 0.3 | 0.5 | 0.1 |
| Social capital | 1.4 | 0.6 | 0.4 | 0.3 | 0.2 | 0.2 |
| sum | 7.2 | 11.1 | 4.1 | 22.7 | 37.6 | 23.2 |
| Metabolites | ||||||
| 3-Hydroxyisobutyrate | ||||||
| NMR | 1.2 | NA | 0.6 | 6.9 | 2.7 | 5.7 |
| Gamma-linolenyl carnitine | ||||||
| MS C18 | 0.9 | 0.6 | NA | 1.0 | 0.7 | 2.3 |
| l-leucine | ||||||
| MS C18 | 0.9 | 6.9 | 1.0 | NA | 6.1 | 24.4 |
| Uric acid | ||||||
| MS C18 | 0.3 | 2.7 | 0.7 | 6.1 | NA | 8.1 |
| l-gamma-glutamyl-l-leucine | ||||||
| MS C18 | 0.7 | 5.7 | 2.3 | 24.4 | 8.1 | NA |
Abbreviations: HSIC Hilbert–Schmidt independence criterion, CES-D Center for Epidemiologic Studies-Depression Scale, BMI body mass index, LSNS-6 Lubben Social Network Scale 6, NMR nuclear magnetic resonance spectroscopy, MS C18 mass spectrometry in C18 mode.