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. 2020 May 19;10:8250. doi: 10.1038/s41598-020-64931-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Rheological studies of goat eye vitreous treated with CBD/RCBD vitreous: (Panel A) Experimental set-up; (Panel B) Measurements of storage modulus (G’) and loss modulus (G”) were done for the control vitreous sample (treated with PBS) and vitreous treated with reagents. Frequency sweeps were recorded at fixed shear strain amplitude (γ○ =3%); linear viscoelastic region (i.e., modulus independent of frequency) is taken within the range of π/5 to 2π rad/s of oscillatory frequency sweep. Error bars indicate standard deviation; (Panel C) Upon treatment of vitreous with CBD, G’ decreased in a dose-dependent manner whereas injection with PBS (control) or BSA (negative control) did not show any change in G’; (D) Both, CBD as well as RCBD-treated vitreous resulted in a significant decrease in storage modulus (P < 0.05). The combination of CBD and RCBD showed a similar effect as seen with individual reagents; (E) The loss tangent (G”/G’) increased significantly in the presence of either reagent used individually, as well as in combination, as compared to control (p < 0.05). (**No of goat eyeballs per treatment group, n = 3).