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. 2020 May 19;10:8295. doi: 10.1038/s41598-020-65110-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed function of the ED and ES for endolymph absorption. An active Na/K-ATPase pump in the ES epithelium causes a longitudinal “flow” that attracts endolymph in the inner ear. Potassium-rich endolymph reaches the ED and is passively leaked through the ED epithelium into surrounding lymph-venous channels. Due to hydrostatic and osmotic forces, the endolymph reaching the ES is rich in sodium.