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. 2020 May 19;11:2493. doi: 10.1038/s41467-020-16323-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The number of oncogenic mutations as a function of the number of in vitro-produced cells. b The probability of oncogenic mutations (x-axis) as a function of the number of in vitro-produced ASCs (primary y-axis,) and as a function of years of adult life (secondary y-axis). c The probability of BRAF^V600E mutations (x-axis) as a function of the number of in vitro-produced ASCs (primary y-axis), and as a function of years of adult life (secondary y-axis).