Table 3.
Univariate and multivariate cox regression analyses for overall survival in cervical cancer patients in matched (1:1) dataset.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Age | ||||
| ≤ 45 years vs. >45years | 0.83 (0.56–1.23) | 0.354 | – | – |
| Histological grade | 0.062 | |||
| G1 | Ref. | – | – | |
| G2 | 0.95 (0.44–2.06) | 0.903 | – | – |
| G3 | 1.68 (0.80–3.52) | 0.169 | – | – |
| Tumor size | ||||
| >4 vs. ≤4 | 2.76 (1.83–4.16) | <0.001* | 1.74 (1.09–2.76) | 0.020* |
| Tumor invasion depth | ||||
| >1/2 vs. ≤1/2 | 2.24 (1.46–3.46) | <0.001* | 1.51 (0.95–2.41) | 0.083 |
| Lymphovascular invasion | ||||
| Yes vs. No | 2.29 (1.50–3.50) | <0.001* | 2.04 (1.28–3.24) | 0.003* |
| 2018 FIGO stage | <0.001* | <0.001* | ||
| IA | Ref. | Ref. | ||
| IB | 3.15 (1.49–6.64) | 0.003* | 2.41 (1.11–5.25) | 0.026* |
| IIA | 8.38 (3.92–17.91) | <0.001* | 6.14 (2.64–14.30) | <0.001* |
| Radiotherapy | ||||
| Yes vs. No | 1.17 (0.74–1.87) | 0.724 | ||
| Chemoradiotherapy | ||||
| Yes vs. No | 1.28 (0.69–2.40) | 0.436 | ||
| SIRI | ||||
| >1.25 vs. ≤1.25 | 1.96 (1.30–2.94 | 0.001* | 1.82 (1.20–2.76) | 0.005* |
FIGO, International Federation of Gynecology and Obstetrics; SIRI, systemic inflammation response index; HR, hazard ratio; CI, confidence interval; Ref, reference.
*
Statistically significant (P < 0.05).