Table 1.

P2Y12 inhibitors in clinical use.

	Dose	Pharmacokinetics	Contraindications	Adverse effects
Clopidogrel	300 or 600 mg loading dose followed by 75 mg daily for maintenance	Prodrug that is metabolized to a pharmacologically active metabolite	Anaphylactic reaction	Generally well-tolerated but may have an allergic reaction with diffuse urticaria
Prasugrel	60 mg loading dose followed by 10 mg daily for maintenance	Prodrug that is metabolized to a pharmacologically active metabolite and inactive metabolites	Absolute contraindication: history of stroke or TIA Relative contraindication: ≥75 years of age or patient weight <60 kg	Generally well-tolerated. Like clopidogrel may have diffuse urticaria
Ticagrelor	180 mg loading dose followed by 80 mg twice daily for maintenance	Not a prodrug and does not require bioactivation	Anaphylactic reaction	Dyspnea in 14%