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. 2020 May 13;11:258. doi: 10.3389/fendo.2020.00258

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Copyright © 2020 Villalba, Rodriguez-Fernandez, Perna-Barrull, Ampudia, Gomez-Muñoz, Pujol-Autonell, Aguilera, Coma, Cano-Sarabia, Vázquez, Verdaguer and Vives-Pi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of the effect of liraglutide in the induction of bihormonal insulin⁺ glucagon⁺ cells. Triple immunofluorescence staining of 5-μm cryostat pancreatic sections for α-cells (glucagon, green) and β-cells (insulin, red) in immunodeficient NOD.SCID-IL2Rγ^−/− mice rendered diabetic by streptozotocin and treated with phosphate-buffered saline (T1D), or with liraglutide for 48 h (Lira 48 h), for 7–15 days (Lira) and after withdrawal of liraglutide at day 30 (post-Lira). Normoglycemic mice were included as control (sham). The white arrows in Lira 48 h staining depict bihormonal cells. The nuclei in all pictures were stained with Hoechst (blue). The scale bar indicates 5 μm.