Figure 4.

Effect of alendronate or calcium supplement on osteoclast morphology in mice under long term rabeprazole treatment. Photomicrographs for bone sections stained with hematoxylin and eosin in different experimental groups. (A) Vehicle group showing bone marrow containing osteoclast as a large cell has multiple nuclei (N), clear zone (C) and short cytoplasmic processes (arrow head). (B) Rabeprazole group showing bone marrow containing osteoclast as a large cell has multiple nuclei (N), prominent clear zone (C) and long cytoplasmic processes (arrow head). (C) Rabeprazole + Calcium group showing bone marrow containing osteoclast as a large cell has multiple nuclei (N), prominent clear zone (C) and long cytoplasmic processes (arrow head). (D) Rabeprazole + Alendronate group showing bone marrow containing quiescent osteoclast as a large cell has two inactive nuclei (N), and short cytoplasmic processes (arrowhead).