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. 2020 May 19;11:2501. doi: 10.1038/s41467-020-16198-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Experimental design for (b–d). Ten microliters of CFA or NS was injected into the hind paw, and AAV-hSyn-DIO-hM4Di-eGFP (0.4 μl) and CNO (0.5 mM, 1 μl) or NS were microinjected into the vmPFC of nNOS-Cre mice on the indicated day. b–d Distance in center (b, left) and total distance (b, right) in an OF test, time in open arms (c, left) and total entries in arms (c, right) of an EPM test, and withdrawal threshold of hind paw in a von Frey test (d) 3 days after CFA or NS injection. n = 14. e Experimental design for (f–h). Chronic neuropathic pain was induced by spinal nerve ligation (SNL). AAV-hSyn-DIO-hM4Di-eGFP (0.4 μl) was microinjected into the vmPFC of nNOS-Cre mice, and CNO (2 mg per kg) or NS was injected intraperitoneally. f–h Distance in center (f, left) and total distance (f, right) in an OF test, time in open arms (g, left) and total entries in arms (g, right) of an EPM test and withdrawal threshold of the hind paw in a von Frey test (h) 7 days after SNL or sham operation. n = 13. Data are the mean ± SEM; *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA followed by Tukey’s post hoc test). Source data are provided as a Source data file. Exact p values and additional statistical information can be found in Source data.