Table 8.
Medication characteristics and effect on weight loss, off-label patients—unadjusted analyses.
| Medication | Medication Instances, n (%) | Instances with complete weight information, n (%)¥ | Pre-medication BMI, kg/m2 mean (95% CI) | Duration of use, years mean (95% CI) | Maximum weight loss, %TBW mean (95% CI)‡ |
Final weight loss, %TBW mean (95% CI)‡ |
|---|---|---|---|---|---|---|
| Young adults (19–25 years old) | ||||||
| Metformin | 257 (33.1) | 126 (49.0) | *41.5 (40.2–42.7) | 1.73 (0.8–2.7) | 2.66 (1.5–3.9) | −1.11 (−2.7–0.4) |
| Topiramate | 299 (38.5) | 142 (47.5) | *38.3 (37.2–39.4) | 1.94 (1.7–2.2) | 3.53 (2.4–4.6) | 0.62 (−0.7–1.9) |
| Bupropion | 21 (2.7) | 8 (38.1) | 37.8 (32.0–43.7) | 1.63 (0.7–2.6) | *-4.91 (−9.9–0.1) | −6.68 (−14.0–0.6) |
| Phentermine | 142 (18.3) | 75 (52.8) | 41.5 (39.7–43.3) | 0.84 (−0.9–2.5) | 4.42 (3.1–5.8) | 1.17 (−0.3–2.6) |
| Zonisamide | 16 (2.1) | 6 (37.5) | 40.9 (31.5–50.2) | 1.23 (0.3–2.2) | 3.93 (−2.3–10.2) | −2.89 (−8.3–2.5) |
| Naltrexone | 18 (2.3) | 6 (33.3) | 37.8 (32.5–43.1) | 1.15 (0.2–2.1) | 3.75 (0.1–7.4) | *3.29 (1.4–5.2) |
| Orlistat | 23 (3.0) | 13 (56.5) | 40.9 (37.7–44.2) | *0.76 (0.4–1.1) | *0.90 (−0.5–2.3) | −2.24 (−4.8–0.3) |
| Overall | 776 (100.0) | 376 (48.5) | 40.2 (39.4–40.9) | 1.59 (1.1–2.0) | 3.19 (2.5–3.9) | −0.12 (−0.9–0.7) |
| Adolescents (13–18 years old) | ||||||
| Metformin | 175 (50.9) | 93 (53.1) | *2.39 (2.3–2.5) | 1.90 (1.6–2.2) | *0.03 (0.0–0.1) | −0.03 (−0.1–0.0) |
| Topiramate | 122 (35.5) | 52 (42.6) | *2.17 (2.1–2.3) | 1.98 (1.6–2.4) | 0.08 (0.0–0.1) | −0.05 (−0.1–0.0) |
| Phentermine | 47 (13.7) | 23 (48.9) | 2.36 (2.2–2.5) | 1.82 (1.3–2.3) | *0.24 (0.1–0.4) | *0.12 (0.0–0.2) |
| Overall | 344 (100.0) | 168 (48.8) | 2.32 (2.3–2.4) | 1.92 (1.7–2.1) | 0.07 (0.0–0.1) | −0.01 (0.0–0.0) |
| Children (5–12 years old) | ||||||
| Metformin | 24 (49.0) | 13 (54.2) | 2.51 (2.4–2.7) | 2.30 (1.4–3.2) | 0.07 (0.0–0.2) | −0.03 (−0.1–0.1) |
| Topiramate | 25 (51.0) | 14 (56.0) | 2.36 (2.2–2.5) | 2.20 (1.4–3.0) | 0.09 (0.0–0.2) | 0.02 (−0.1–0.2) |
| Overall | 49 (100.0) | 27 (55.1) | 2.43 (2.3–2.5) | 2.25 (1.7–2.8) | 0.08 (0.0–0.2) | 0.00 (−0.1–0.1) |
*
Statistically significant difference when compared to the overall frequency-weighted mean, p < 0.05.
¥
Complete weight information indicates patients with both start and end weights recorded in chart.
‡
Negative weight loss indicates weight gain.