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. 2020 May 13;11:402. doi: 10.3389/fphys.2020.00402

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Copyright © 2020 Dinh, Lidington, Kroetsch, Ng, Zhang, Nedospasov, Heximer and Bolz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Subarachnoid hemorrhage (SAH) induces a cardiovascular phenotype. At 2-days post-SAH induction, (A) plasma epinephrine levels are elevated (sham n = 8, SAH n = 10), (B) cardiac output is reduced (sham n = 35, SAH n = 35) and (C) total peripheral resistance is elevated (sham n = 7, SAH n = 8). (D) The elevated peripheral resistance correlates with augmented cremaster skeletal muscle resistance artery myogenic tone (sham dia_max: 78 ± 2 μm, n = 26; SAH 78 ± 2 μm, n = 22). (E) Phenylephrine-stimulated vasoconstriction is also greater in cremaster arteries isolated from SAH mice (sham dia_max: 78 ± 2 μm, n = 26; SAH 78 ± 2 μm, n = 22); however, (F) calcium sensitivity is unaffected (sham dia_max: 72 ± 5 μm, n = 7; SAH dia_max: 80 ± 3 μm, n = 8). *P < 0.05.