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. 2020 May 13;11:402. doi: 10.3389/fphys.2020.00402

FIGURE 3.

FIGURE 3

α-Adrenergic signaling drives the vascular phenotype in SAH, but not the cardiac phenotype. (A) Terazosin (TZ; twice daily for 2 days with i.p. injections; 1 mg/kg initial pre-operative dose followed by 0.5 mg/kg for all subsequent injections) has no effect on the compromised cardiac function observed at 2-days post-SAH induction (sham n = 16, SAH n = 16, SAH + TZ n = 12). (B) However, terazosin treatment successfully normalizes the augmented myogenic reactivity in cremaster skeletal muscle arteries isolated from SAH mice. (C) Phenylephrine responses are enhanced in cremaster arteries isolated from SAH mice; this augmentation is also normalized by terazosin treatment (sham diamax: 76 ± 3 μm, n = 13; SAH diamax: 76 ± 3 μm, n = 12; SAH + TZ diamax: 74 ± 2 μm, n = 13). (D) Calcium sensitivity is not altered by terazosin treatment (SAH diamax: 80 ± 3 μm, n = 8; SAH + TZ diamax: 78 ± 4 μm, n = 7). The SAH curve in (D) is reproduced from Figure 1E for comparison to the SAH + TZ curve. *P < 0.05.