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. 2020 May 13;11:402. doi: 10.3389/fphys.2020.00402

FIGURE 5.

FIGURE 5

Tumor necrosis factor (TNF) gene deletion abolishes the SAH-induced myogenic tone augmentation. In cremaster skeletal muscle resistance arteries isolated from germline tumor necrosis factor knockout mice (TNF KO), neither (A) myogenic tone nor (B) phenylephrine responses are affected by SAH (at 2-days post-SAH induction; sham diamax: 69 ± 4 μm, n = 7; SAH diamax: 71 ± 6 μm, n = 6). Accordingly, in cremaster skeletal muscle resistance arteries isolated from smooth muscle cell-targeted tumor necrosis factor knockout mice (sm-TNF KO), neither (C) myogenic tone (sham diamax: 90 ± 4, n = 6; SAH diamax: 77 ± 7, n = 6) nor (D) phenylephrine responses are affected by SAH (sham diamax: 90 ± 4, n = 6; SAH diamax: 72 ± 6, n = 7).