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. 2020 May 13;11:402. doi: 10.3389/fphys.2020.00402

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Copyright © 2020 Dinh, Lidington, Kroetsch, Ng, Zhang, Nedospasov, Heximer and Bolz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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∝-adrenergic signaling augments myogenic reactivity and calcium sensitivity despite tumor necrosis factor (TNF) gene deletion. Cremaster skeletal muscle resistance arteries isolated from TNF KO mice were treated for 4 h with either 1 μmol/L phenylephrine or control buffer in vitro. The arteries were then washed and assessed in normal buffer. Arteries treated with phenylephrine display higher (A) myogenic reactivity (control dia_max: 71 ± 4 μm, n = 5; phenylephrine dia_max: 70 ± 3 μm, n = 6) and (B) calcium sensitivity (control dia_max: 68 ± 6 μm, n = 5; phenylephrine dia_max: 69 ± 4 μm, n = 5) than control arteries; however, the treatment does not affect (C) responses to phenylephrine (control dia_max: 68 ± 6 μm, n = 5; phenylephrine dia_max: 69 ± 4 μm, n = 5). *P < 0.05.