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Cones in lecithin-retinol acyltransferase deficient (Lrat−/−) mice exhibit proteasome insufficiency. The retinal sections from P18 Lrat−/−UbG76V-GFP and UbG76V-GFP control mice were labeled with an anti–green fluorescent protein (GFP) antibody (green). Cones were labeled with rhodamine–peanut agglutinin (red). Nuclei were stained with DAPI. Scale bars = 10 μm. CIS, cone inner segment; COS, cone outer segment; ONL, outer nuclear layer; OPL, outer plexiform layer.
