Supplemental Figure S2.

Determination of epithelial marker expression. Immunohistochemical expression of cytokeratin 18 (CK-18) (A) and E-cadherin (B) (arrows). Biliary expression of CK-18 and E-cadherin increases in multidrug-resistance transporter 2/ABC transporter B family member 2 knockout mouse (Mdr2^−/−) mice treated with mismatch compared with wild-type (WT) mice. Expression of CK-18 (A) and E-cadherin (B) is more enhanced in Mdr2^−/− mice treated with histamine-2 receptor (H2HR) vivo-morpholino compared with mismatch treated mice. No differences are seen between WT groups. Original magnification: ×40 (A and B, main images); ×100 (A and B, insets).