Table 2.

Summary of Profiling of Atherosclerotic Lesion Composition

Lesion feature	Males		Females
	apoE−/−	apoE−/−.FAP−/−	apoE−/−	apoE−/−.FAP−/−
Aortic lesion burden	+	++	+	++
Root lesion size	+	++	++	++
Lipid content	+	+	+	+
Total collagen	+	+	+	+
Fibrillar collagen	+	+	+	+
Col1	++	+	++	++
Fn1	++	++	++	+
Col1/Fn1 colocalization	+	+	+	+
Col1 only (no overlap with Fn1)	++	+	++	+++
Fn1 only (no overlap with Col1)	++	++	++	+
Vcam1	+	+	+	+
Acta2	++	+	++	++
Fibrotic caps	+	+	+	+
Cap thickness	+	+	+	+
Cap length	+	+	+	+
Adgre1+ leukocytes	++	++	++	+
Cd68+ inflammatory cells	++	++	++	+
M1 macrophages	++	++	+	+
M2 macrophages	+	+	+	+
Mox macrophages	++	++	++	+

Lesion feature detected at moderate (+), increased (++), and highly abundant (+++) levels.

Acta2, α-smooth muscle actin; Adgre1, adhesion G protein–coupled receptor E1; Col1, collagen type I; Fn1, fibronectin; Vcam1, vascular cell adhesion molecule 1.