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A) Steps in viral and nonviral‐mediated CAR transfer methods. After the integration of CAR encoding genes in virus vectors, the virus binds to the cell membrane (i) and releases the encoding gene into the nucleus (ii) by endocytosis so that it can integrate (iii), replicate (iv), and translate into mRNA (v), resulting in the internalization and expression of the CAR gene (vi–ix). B) Representative nonviral‐mediated CAR transfer strategies and associated mechanisms.
