Table 2.

Generation of CAR‐T cells by viral vectors followed by fatal or serious adverse effects

Viral vector	Center	Disease	No. of patients/outcome	Adverse effects	Ref.
γ‐Retroviral	NCI	B lymphomas	8/6 remission	Tumor lysis	[ 52 ]
		Post‐stem cell transplantation	10/3 regression	B cell aplasia and hypotension	[ 53 ]
	Baylor	NHL	6/2 responses	Cytokine release syndrome	[ 54 ]
		Allo‐stem cell transplantation	8/2 responses	Cytokine release syndrome	[ 55 ]
	MSKCC	CLL	8/1 response	Death and B cell aplasia	[ 56 ]
		ALL	5/5 minimal residual disease	Cytokine release syndrome	[ 17, 57 ]
Lentiviral	UPENN	CLL	3/2 complete response and 1 partial response	Tumor lysis syndrome	[ 44, 58 ]

NCI, National Cancer Institute; NHL, non‐Hodgkin lymphoma; MSKCC, Memorial Sloan Kettering Cancer Center; CLL, chronic lymphocytic leukemia; ALL, acute lymphocytic leukemia; UPENN, University of Pennsylvania.