Figure 5.

In vivo imaging and therapeutic assessment. a) Representative SPECT/CT images of SW1990 tumor‐bearing mice at different time points after intratumoral injection of ¹²⁵I and ¹²⁵I‐TiO₂. b) Representative photographs of SW1990 tumor‐bearing mice for time‐course change of tumor size after different treatments including DMEM (control), ¹²⁵I, and ¹²⁵I‐TiO₂. c) Tumor growth curves during the 20 d observation after different treatments by DMEM (control), ¹²⁵I, and ¹²⁵I‐TiO₂. Relative tumor volume (V V ₀ ⁻¹) was given by tumor volume (V) normalized to the initial value (V ₀) (n = 5, mean ± s.d., Kruskal–Wallis one‐way ANOVA analysis, P = 0.048 (¹²⁵I‐TiO₂ vs ¹²⁵I) and 0.001 (¹²⁵I‐TiO₂ vs Control), *P < 0.05, **P < 0.01). d) Survival curves of mice after different treatments during an observation period of 60 d (n = 8). e) H&E staining of tumor sections harvested at day 20 post different treatments (original magnification 200 ×). f) Representative TUNEL staining of tumor slices collected at day 20 post treatments (original magnification 200 ×).