Table 2.

Associations between image features and DNAm.

Image Feature (number of studies)	Differential DNAm: gene or feature
Global fractional anisotropy (n = 2)	DNAm age (Horvath) DNAm age (Hannum)
Regional fractional anisotropy (n = 6)
•Corpus callosum	SLC6A4 FMR1 DNAm age (Hannum)
•Ventrolateral thalamus •Right anterior corona radiata •Right parahippocampal cingulum	SMOC2 BDNF TESC
Regional radial, mean or axial diffusivity (n = 5) •Inferior and middle cerebellar peduncle •Corpus Callosum •Right anterior corona radiata •Right parahippocampal cingulum	FMR1 DNAm age (Hannum) SLC6A4 BDNF TESC
Amygdala functional connectivity (n = 9)	SLC6A4 SLC6A4 SLC6A4 SLC6A3/DAT SLC6A4 OXTR OXTR SLC6A4 SLC6A4
Hippocampal functional connectivity (n = 4)	SLC6A4 Cluster of genes identified through EWAS (Wang et al., 2017)* Cluster of genes identified through EWAS (Hu et al., 2018)* BDNF
Prefrontal cortex functional connectivity (n = 8)	FKBP5 MB-COMT BDNF NR3C1 HTR3A COMT SLC6A4 BDNF
Hippocampal volume (n = 11)	BDNF SLC6A4 TESC DNAm age (Horvath) Cluster of genes identified through EWAS (Hass et al., 2015)* OXTR DNAm age (Hannum) FKBP5 NR3C1-1F SLC6A4 FKBP5
Cortical volume (n = 2)	Cluster of genes identified through EWAS (Casey et al., 2017)* Cluster of genes identified through EWAS (Liu et al., 2015)*
Cortical thickness (n = 6)	SLC6A4 BDNF FKBP5 FMR1 SKA2 Independent component of DNAm (Freytag et al., 2017)
PFC (volume/thickness) (n = 2)	OXTR SKA2

*See Table 3, Table 4, Table 5, Table 6, Table 7, Table 8, Table 9 for list of genes included in clusters identified by EWAS.