REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Zombie Aqua Fixable Viability Kit	Thermo Fisher	Catalog number: L34965
Alexa Flour 700 anti-mouse CD11b	BD Bioscience	Catalog number: 557960; RRID: AB_396960
PE/Cy7 anti-mouse CD11c	BioLegend	Catalog number: 117317; RRID: AB_493569
Brilliant Violet 421 anti-mouse F4/80	BioLegend	Catalog number: 123131; RRID: AB_10901171
APC-eFluor 780 anti-mouse Ly6C	Thermo Fisher	Catalog number: 47-5932-82; RRID: AB_2573992
PerCP/Cy5.5 anti-mouse Ly-6G	BioLegend	Catalog number: 127653; RRID: AB_2616998
Brilliant Violet 650 anti-mouse NK-1.1	BioLegend	Catalog number: 108735; RRID: AB_11147949
Brilliant Violet 605 anti-mouse CD335	BioLegend	Catalog number: 137619; RRID: AB_2562452
FITC anti-mouse CD169	BioLegend	Catalog number: 142405; RRID: AB_2563106
APC anti-mouse CD209b	Thermo Fisher	Catalog number: 17-2093-82;RRID: AB_11151692
FITC anti-mouse T1/IL1RL1 (ST2)	MD Biosciences	Catalog number: 101001; RRID: AB_947549
FITC anti-mouse Ter119	BioLegend	Catalog number: 116205; RRID: AB_313706
PE-anti-mouse CD71	BioLegend	Catalog number: 113807; RRID: AB_313568
APC anti-mouse DYKDDDDK	BioLegend	Catalog number: 637307; RRID AB_2561496
Brilliant Violet 570 anti-mouse CD45.1	BioLegend	Catalog number: 110733; RRID: AB_10895765
Brilliant Violet 785 anti-mouse CD45.2	BioLegend	Catalog number: 109839; RRID: AB_2562604
APC anti-mouse CD45	BioLegend	Catalog number: 103111; RRID: AB_312976
anti-mouse IL-33 antibody	R&D systems	Catalog number: AF3626; RRID: AB_884269
anti-human IL-33 antibody	R&D systems	Catalog number: AF3625; RRID: AB_1151900
anti-human IL-33 antibody	BioRad	Catalog number: AHP1482; RRID: AB_2124144
anti-human IL-33 antibody	BioRad	Catalog number: AHP1626; RRID: AB_2124143
p44/42 MAPK (Erk1/2) Antibody	Cell Signaling	Catalog number: 9102; RRID: AB_330744
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) antibody	Cell Signaling	Catalog number: 9101; RRID: AB_331646
Phospho-NF-κB p65 antibody	Cell Signaling	Catalog number: 3033; RRID: AB_331284
anti-CD235a (Glycophorin A) MicroBeads, human	Miltenyi Biotec	Catalog number: 130-050-501
anti-Ter-119 MicroBeads, mouse	Miltenyi Biotec	Catalog number: 130-049-901
Chemicals, Peptides, and Recombinant Proteins
Hemin	Sigma	Catalog number: 51280
U0126	Sigma	Catalog number: 662005
Recombinant Mouse IL-33 (carrier-free)	BioLegend	Catalog number: 580502
Recombinant Human IL-33 (carrier-free)	BioLegend	Catalog number: 581802
Soluble IL1RL1 (ST2)	AstraZeneca	Catalog number: N/A
Murine IgG1	AstraZeneca	Catalog number: N/A
Recombinant Mouse M-CSF (carrier-free)	BioLegend	Catalog number: 576402
Recombinant Human M-CSF (carrier-free)	BioLegend	Catalog number: 574802
Tn5 transposase	Illumina	Catalog number: 15027865
Transposase buffer	Illumina	Catalog number: 15027866
AMPure XP beads	Beckman Coulter	Catalog number: A63880
Critical Commercial Assays
Human Phospho-Kinase Array Kit	R&D systems	Catalog number: ARY003B
PKH26 Red Fluorescent Cell Linker Kits	Sigma	Catalog number: MINI26
V-PLEX Plus Mouse IL-33 Kit	MesoScale Discovery	Catalog number: K152XBD-1
Human IL-33 Duoset ELISA kit	R&D systems	Catalog number: DY3625
SMARTer stranded total RNA-Seq v2 kit	Takara	Catalog number: 634412
RNEasy plus micro kit	Qiagen	Catalog number: 74034
Minelute PCR purification cleanup kit	Qiagen	Catalog number: 28004
Tools
STAR 2.5.1	https://github.com/alexdobin/STAR/releases/tag/2.5.1b	RRID: SCR_015899
cutadapt 2.5	https://pypi.org/project/cutadapt/2.5/	RRID: SCR_011841
Python 3.6.2		RRID: SCR_008394
Subread-Feature Counts 1.6.2	https://sourceforge.net/projects/subread/files/subread-1.6.2/	RRID: SCR_009803
DESeq2 1.25.9	http://bioconductor.org/packages/release/bioc/html/DESeq2.html	RRID: SCR_015687
heatmap.2 function from the R Package gplots 3.0.1.1	https://cran.r-project.org/src/contrib/Archive/gplots/.	N/A
Ingenuity Systems Pathway analysis software	Qiagen	RRID: SCR_008653
TrimGalore	https://github.com/FelixKrueger/TrimGalore/releases/tag/0.6.4	RRID: SCR_011847
Bowtie2	https://sourceforge.net/projects/bowtie-bio/files/bowtie2/2.3.5.1	RRID: SCR_005476
Genrich	https://github.com/jsh58/Genrich#quick	N/A
BEDtools 2.29.0	https://github.com/arq5x/bedtools2/releases/tag/v2.29.0	RRID: SCR_006646
Meme-Chip	http://meme-suite.org/index.html	RRID: SCR_001783
Data deposition
Sequencing data	GEO	GSE146782