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SARS-CoV-2 Epitope Reactivity in Unexposed Individuals
(A) SARS-CoV-2-reactive CD4+ T cells measured as percentage of AIM+ (OX40+CD137+) CD4+ T cells in unexposed (n = 11) donors.
(B) FACS plot examples, gated on total CD4+ T cells.
(C) Plasma IgG ELISAs for seroreactivity to RBD of HCoV-OC43 or HCoV-NL63. Data are expressed as geometric mean and geometric SD.
Pairwise statistical comparisons (A) were performed with the Wilcoxon test. ∗p < 0.05; ns, not significant.
