Table 2.

Immunodominant T Cell Epitopes Identified in SARS-CoV

T cell epitopes	Protein	Peptide position	Sequencea	HLA-restriction	Refs
CD4 T cell immunodominant epitopes
	Spike	159–171	CTFEYISDAFSLD	HLA-DRB1*0401 and HLA-DRB1*0701	[95]
	Spike	166–178	DAFSLDVSEKSGN	HLA-DRB1*0401	[95]
	Spike	358–374	STFFSTFKCYGVSATKL	HLA-DR	[96]
	Spike	427–444	NIDATSTGNYNYKYRYLR	HLA-DR	[96]
	Spike	449–461	RPFERDISNVPFS	HLA-DRB1*0401	[95]
	Spike	729–745	TECANLLLQYGSFCTQL	HLA-DR	[96]
	Spike	1083–1097	SWFITQRNFFSPQII	HLA-DRB1*0401	[95]
	Nucleocapsid	346–362	N.A.b	N.A.	[97]
CD8 T cell immunodominant epitopes
	Spike	411–420	KLPDDFMGCV	HLA-A*02:01	[98]
	Spike	787–795	ILPDPLKPT	HLA-A*02:01	[99]
	Spike	940–948	ALNTLVKQL	HLA-A*02:01	[100]
	Spike	958–966	VLNDILSRL	HLA-A*02:01	[101]
	Spike	978–986	LITGRLQSL	HLA-A*02:01	[102]
	Spike	1042–1050	VVFLHVTYV	HLA-A*02:01	[99]
	Spike	1167–1175	RLNEVAKNL	HLA-A*02:01	[103]
	Spike	1174–1182	NLNESLIDL	HLA-A*02:01	[100]
	Spike	1203–1211	FIAGLIAIV	HLA-A*02:01	[102]
	Nucleocapsid	216–225	GETALALLLL	HLA-B*40:01	[104]
	Nucleocapsid	223–231	LLLDRLNQL	HLA-A*02:01	[99]
	Nucleocapsid	227–235	RLNQLESKV	HLA-A*02:01	[99]
	Nucleocapsid	317–325	GMSRIGMEV	HLA-A*02:01	[99]
	Nucleocapsid	331–347	N.A.	N.A.	[97]
	Nucleocapsid	346–362	N.A.	N.A.	[97]

^aUnderlined sequences indicate identical amino acids between SARS-CoV (GenBank accession number: NC_004718.3) and SARS-CoV-2 (GenBank accession number: MN908947.3).

^bPeptide sequence was not included in the original article.