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. 2020 May 20;51(6):473–481. doi: 10.1016/j.arcmed.2020.05.007

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© 2020 IMSS. Published by Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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A Model of coronavirus entry and replication inside the host cell: After receptor recognition virus binds with host cell Ace2 receptor. TMPRSS (Trans-membrane Serine Protease) facilitated viral entry, uncoating followed by transcription and translation of viral genome (Replication complex) with the release of viral protein. Viral replication in the host cells induces ER stress due to close association of several stages of the coronavirus replication cycle with the endoplasmic reticulum (ER) producing viral proteins (VP) later forms new virion.