Table 2.
Additional kinetoplastid proteins with both experimental evidence and a signal sequence indicating localization to the glycosome. Proteins are grouped by major KEGG pathway inclusion. It was not possible to assign a best KEGG orthologue for all proteins.
| KEGG Reference Ortholog | Major KEGG Pathway | Name of Protein | PTS1/PTS2 |
|---|---|---|---|
| K00845 | Glycolysis | Glucokinase | PTS1 |
| K01809 | Glycolysis/gluconeogenesis | Phosphomannose isomerase | PTS1 |
| K17497 | Glycolysis/gluconeogenesis | Phosphomannomutase-like protein | PTS1 |
| K00849 | Glycolysis/gluconeogenesis | Galactokinase-like protein | PTS1 |
| K02564 | Glycolysis/gluconeogenesis | Glucosamine-6-phosphate isomerase | PTS1 |
| K00927 | Glycolysis/gluconeogenesis | Pas-domain containing phosphoglycerate kinase | PTS1 |
| K01443 | Glycolysis/gluconeogenesis | N-acetylglucosamine-6-phosphate deacetylase-like protein | PTS1 |
| K00863 | Glycolysis/gluconeogenesis | Dihydroxyacetone kinase 1-like | PTS1 |
| K01518 | Purine metabolism | Kinetoplastid-specific phospho-protein phosphatase | PTS1 |
| K00759 | Purine metabolism | Adenine phosphoribosyltransferase | PTS1 |
| K00853 | Pentose phosphate pathway | L-ribulokinase | PTS1 |
| K06128 | Glycerophospholipid metabolism | Lysophospholipase | PTS1 |
| Fatty acid metabolism | Acyl-CoA binding protein | PTS1 | |
| K00311 | Fatty acid metabolism | Electron transfer flavoprotein-ubiquinone oxidoreductase | PTS1 |
| K13356 | Fatty acid metabolism | Fatty acyl- CoA reducatase | PTS1 |
| K00632 | Fatty acid metabolism | 3-ketoacyl- CoA thiolase | PTS2 |
| Fatty acid epoxide hydrolase | Epoxide hydrolase | PTS1 | |
| K04283 | Redox maintenance | Trypanothione-disulfide reductase | PTS1 |
| K11185 | Redox maintenance | Tryparedoxin peroxidase | PTS1 |
| Redox maintenance | Dj-1 family protein | PTS1 | |
| K04564 | Redox maintenance | Iron superoxide dismutase | PTS1 |
| K04564 | Redox maintenance | Iron superoxide dismutase | PTS1 |
| Redox maintenance | 2-oxoglutarate (2og) and Fe(II)-dependent oxygenase superfamily protein | PTS1 | |
| K01940 | Urea cycle | Arginino-succinate synthase | PTS1 |
| K01438 | Urea cycle | Acetylornithine deacetylase-like | PTS1 |
| K01745 | Amino acid degradation | Histidine ammonia-lyase | PTS1 |
| K02614 | Amino acid degradation | Thioesterase-like superfamily | PTS1 |
| Peptide cleavage | Peptidase T | PTS2 | |
| Protein cleavage | Carboxypeptidase M32 | PTS2 | |
| K02150 | pH regulation | V-ATPase, subunit E | PTS1 |
| Pyrophosphate and poly phosphate metabolism | Acidocalcisomal exopolyphosphatase | PTS1 | |
| K02218 | Signal pathway regulation | Casein kinase I, isoform 2 | PTS2 |
| K01676 | TCA cycle | Fumarate hydratase, class I (FHM) | PTS2 |
| K00972 | Amino and nucleotide sugar metabolism | UDP-N-acetylglucosamine pyrophosphorylase | PTS1 |
| N/A | Hypothetical protein (Q4DBW4) | PTS1 | |
| N/A | Hypothetical protein (Q57TT5) | PTS1 | |
| N/A | Hypothetical protein (Q381V8) | PTS1 |