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. 2020 Apr 1;12(4):314. doi: 10.3390/pharmaceutics12040314

Table 1.

Concentrations (µg/mL) of triazoles (fluconazole and itraconazle) or imidazoles (ketoconazole, clotrimazol, miconazole) leading to either ≥ 50 or ≥ 90% growth inhibition (g.i.) of C. albicans CAF2-1 strain. These values were given alone or in combination with surfactin (SU) (µg/mL) towards C. albicans CAF2-1 strain. Fractional inhibitory concentration indexes (FICIs) were included in bracelets.

Azole ≥50% g.i. ≥50% g.i. ≥50% g.i. ≥90% g.i. ≥90% g.i. ≥90% g.i.
16 µg/mL SU 32 µg/mL SU 16 µg/mL SU 32 µg/mL SU
Triazoles
Fluconazole 2 0.5 0.5 >256 1 0.5
(FICI = 0.258) (FICI = 0.258) (FICI < 0.012) (FICI < 0.010)
Itraconazole 0.0313 0.0078 0.0039 >8 0.0156 0.0078
(FICI = 0.257) (FICI = 0.132) (FICI < 0.010) (FICI < 0.009)
Imidazoles
Ketoconazole 0.0039 0.0039 0.0039 4 0.0078 0.0078
(FICI = 1.008) (FICI = 1.008) (FICI = 0.010) (FICI = 0.010)
Clotrimazole 0.0156 0.0156 0.0156 1 0.0313 0.0313
(FICI = 1.008) (FICI = 1.008) (FICI = 0.039) (FICI = 0.039)
Miconazole 0.0156 0.0156 0.0156 2 0.0313 0.0156
(FICI = 1.008) (FICI = 1.008) (FICI = 0.023) (FICI = 0.016)