Table 1.

Pharmacokinetic parameters of VLP and VLP-MSNs after single dose oral administration to rats.

Parameter	VLP	VLP-MSN
t1/2(h)	10.76 ± 0.155	9.20 ± 0.52
AUC 0-t (ng/mL*h)	214.41 ± 1.73	400.50 ± 4.49
Tmax (h)	2	1
Cmax (ng/mL)	16.44 ± 0.48	31.84 ± 0.054
AUC 0-inf (ng/mL*h)	240.61 ± 2.39	428.50 ± 4.53
λz (l/h)	0.074 ± 0.001	0.079 ± 0.00041
MRT 0-inf_obs (h)	15.87 ± 0.12	12.98 ± 0.051