Table 2.
The solubility of acyclovir (ACV) in the [Ch][CA] ILs a at 25 °C and the effects of the viscosity, density, pH, and anionic domain on IL-mediated dissolution b.
| IL or Solvent | Anionic Structure
|
Solubility of ACV (mg/mL) | ρ (g/cm3) | η (m Pa s) | pH |
|---|---|---|---|---|---|
| [Ch][For] | R = -H | 203 ± 12 **** | 1.12 ± 0.03 | 124.7 ± 7 | 5.5 |
| [Ch][Lac] | R = -C2H5O | 208 ± 15 **** | 1.15 ± 0.02 | 897.2 ± 27 | 7.6 |
| [Ch][Pro] | R = -C2H5 | 278 ± 18 **,**** | 1.07 ± 0.02 † | 309.5 ± 12 #### | 6.2 |
| IPM | - | 0.03 ± 0.01 | - | - | - |
| Milli-Q | - | 0.41 ± 0.08 | - | - | - |
a The solubility of ACV in water and IPM is also given. b Data are shown as mean ± SD (n = 3). **** compared with Milli-Q and IPM, p < 0.0001; ** compared with [Ch][For] and [Ch][Lac], p < 0.01; † compared with [Ch][For] and [Ch][Lac, p < 0.05; #### compared with [Ch][For] and [Ch][Lac], p < 0.0001 using Sidak’s multiple comparison test.