Table 1.
lncRNAs reported to be upregulated in various models of cervical lesions and cancers.
| lncRNA | Oncogenic Phenotype | Proposed Mechanism | References |
|---|---|---|---|
| ANRIL | Proliferation, migration, invasion | PI3K/AKT; Cyclin D1, CDK4, CDK6, N-cadherin, Vimentin expression | [27,28] |
| ARAP1-AS1 | Proliferation, invasion | MYC translation by PSF/PTB | [29] |
| BLACAT1 | Proliferation, migration, invasion | WNT signaling/β-catenin | [30] |
| CCAT2 | Proliferation, apoptosis | None reported | [31] |
| CCEPR (CCHE1) | Proliferation | PCNA mRNA stabilization | [32] |
| Proliferation | independent of PCNA mRNA | [33] | |
| CRNDE | Proliferation, migration, invasion | miR-183 sponging/cyclin B1 | [34] |
| Proliferation | PUMA expression | [35] | |
| DANCR | Proliferation, migration, invasion | miR-665 sponging/TGFβ-R1-ERK-SMAD | [36] |
| Proliferation, migration, invasion, epithelial to mesenchymal transition (EMT) | miR-335-5p sponging/ROCK1 | [37] | |
| EBIC (TMPOP2) | Motility, invasion | E-cadherin silencing by EZH2 | [38] |
| Proliferation | miR-375, miR-139 sponging HPV E6/E7 expression |
[39] | |
| FAM83H-AS1 | Proliferation, migration and apoptosis | G1/S-phase transition | [40] |
| GATA6-AS | Migration, invasion | MTK-1 | [41] |
| H19 | Proliferation, anchorage independent growth | None reported | [42] |
| HOTAIR | Apoptosis, invasion, migration | NOTCH signaling | [43] |
| Apoptosis, proliferation, invasion | miR-23b sponging/MAPK1 axis | [44] | |
| Autophagy, EMT | WNT signaling | [45] | |
| Proliferation | miR-143-3p sponging/BCL2 | [46] | |
| HOXD-AS1 | Proliferation | Ras/ERK | [47] |
| Linc00483 | Proliferation, apoptosis, invasion, migration | miR-508-3p sponging/RGS17 | [48] |
| LINP1 | DNA damage repair (Non-homologous end joining) | KU80, DNA-PKcs binding | [49] |
| Lnc-IL7R | Apoptosis | BCL2/caspase 3 | [50] |
| LUCAT1 | Proliferation, migration, invasion | miR-181a sponging | [51] |
| MALAT1 | Cell invasion and metastasis | inhibition of EMT genes | [52] |
| Proliferation, migration, invasion | miR-625-5p/AKT2 | [53] | |
| Proliferation | Mir-625-5p/NF-kB signaling | [54] | |
| Cisplatin resistance | PI3K/AKT | [55] | |
| MIR205HG | Proliferation, apoptosis, migration | SRSF1/KRT17 axis | [56] |
| NEAT1 | Proliferation, invasion | PI3K/AKT | [57,58] |
| Colony formation, migration, invasion | miR-133a sponging/SOX4 | [59] | |
| NORAD | Proliferation, invasion | miR-590-3p sponging/SIP1 | [60] |
| PANDAR | Proliferation | None reported | [61] |
| PVT1 | Proliferation, invasion | Inhibiting TGFβ; miR-140-5p sponging/SMAD3 |
[62,63] |
| EMT, chemoresistance | miR-195 epigenetic silencing | [64] | |
| SNHG8 | Proliferation, apoptosis | RECK silencing by EZH2 | [65] |
| SNHG12 | Proliferation, apoptosis | ERK/Slug | [66] |
| SNHG16 | Proliferation, invasion | PARP9 expression by SPI1 binding | [67] |
| TUG1 | Proliferation, apoptosis, invasion, tumor growth | miR-138-5p sponging/SIRT1 | [68] |
| Proliferation, apoptosis, EMT | BCL-2, caspase 3; fibronectin, vimentin, and cytokeratin | [69] | |
| TP73-AS1 | Proliferation, migration | miR-329-3p sponging/SMAD2 | [70] |
| Proliferation, migration, invasion | miR-607 sponging/CCND2 | [71] | |
| UCA1 | Radioresistance | HK2/glycolytic pathway | [72] |
| XIST | Proliferation | miR-140-5p sponging/ORC1 | [73] |
| Proliferation, invasion, apoptosis, EMT | miR-200a sponging/FUS | [74] | |
| ZEB-AS1 | Proliferation, migration, invasion, EMT | ZEB1 expression | [75] |