Table 2.
lncRNAs reported to be downregulated in various models of cervical lesions and cancers.
| lncRNA | Oncogenic Phenotype | Proposed Mechanism | Reference |
|---|---|---|---|
| GAS5 | Proliferation, invasion, migration | E-cadherin, Vimentin | [76] |
| Proliferation, migration, invasion, colony formation | miR-21 expression/STAT3 | [77] | |
| Radiosensitivity | miR-106b sponging/IER3 | [78] | |
| HOTAIR | Decreased polycomb repression | Binding to HPV E7 | [79] |
| Lnc-CCDST | Migration, invasion, angiogenesis | DHX9, MDM2 scaffolding | [80] |
| MEG3 | Proliferation, apoptosis | Binding, degradation of P-STAT3 | [81] |
| Proliferation, colony formation, apoptosis | miR-21-5p expression/TP53 | [82] | |
| STXBP5-AS1 | Viability, invasion | miR-96-5p expression/PTEN | [83] |
| TINCR | Differentiation, colony formation, migration | S100A8 and other ZNF750 targets | [84] |
| WT1-AS | Proliferation | TP53 | [85] |
| Proliferation, invasion, migration | miR-203a-5p binding/FOXN2 | [86] | |
| XLOC_010588 | Proliferation | MYC mRNA binding/degradation | [87] |