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(A) Release points at 0.5, 3 and 6 h, deviation marks have been removed in order to permit its appreciation (B) Cumulative in vitro release (percentage) of TM for 96 h (5 days) with three different release media PBS, PBS with protease (60 ng/mL) and PBS with MMP-2 (60 ng/mL). Each experiment was carried out by quadruplicate.
