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. 2020 Mar 28;12(4):306. doi: 10.3390/pharmaceutics12040306

Table 1.

Grading system for in vivo tolerance evaluation signs.

Grade Discomfort Cornea Conjunctiva Discharge Lids
0 No reaction No alterations No alterations No discharge No swelling
1 Blinking Mild Opacity Mild hyperemia/mild oedema Mild discharge without moistened hair Mild swelling
2 Enhanced blinking/intense tearing/vocalizations Intense opacity Intense hyperemia/intense oedema/haemorrhage Intense discharge with moistened hair Obvious swelling