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p-values obtained after one-way ANOVA comparison between the reference commercial formulation and timolol-loaded nanoparticle formulations. (* significant differences p < 0.05).
| AUC (0–12) | Maximal mmHg Reduction % | Maximal mmHg Reduction | |
|---|---|---|---|
| TM-GNP3 (TM 0.1%) | p = 0.1581 | p = 0.9376 | p = 0.7339 |
| TM-GNP8 (TM 0.25%) | p = 0.0075 * | p = 0.0119 * | p = 0.0279 * |
| TM-GNP16 (TM 0.5%) | p = 0.0009 * | p = 0.0011 * | p = 0.0011 * |
