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. 2020 Apr 11;12(4):344. doi: 10.3390/pharmaceutics12040344

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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PGE2 amounts in brain tissue samples in control-treated mice, 4 × 250 µg/kg LPS treated mice, 4 × 250 µg/kg LPS treated mice with acute^# treatment of 25 µmol/kg PD1 or KPF, and 4 × 250 µg/kg LPS treated mice with subacute^## treatment of 25 µmol/kg PD1or KPF. Data presented as mean ± SD, n = 6. Asterisks denote a statistically significant difference from the respective control. *** Denotes significance of p < 0.0001, one-way ANOVA, followed by Dunnett’s test. ^# Acute treatment refers to drug injection on the third and fourth days of LPS treatment. ^## Subacute treatment refers to daily drug injection (4 days) simultaneously with the LPS treatment.