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Ki values for inhibition of CYP2C8-catalyzed amodiaquine N-deethylation in human liver microsomes by five biflavonoids.
| P450 Enzyme |
Substrate | Inhibitor | Ki (µM) a | Mode of Inhibition |
|---|---|---|---|---|
| CYP2C8 | Amodiaquine | Selamariscina A | 0.018 ± 0.002 | Noncompetitive |
| Amentoflavone | 0.083 ± 0.009 | Noncompetitive | ||
| Robustaflavone | 0.084 ± 0.016 | Noncompetitive | ||
| Cupressuflavone | 0.103 ± 0.017 | Noncompetitive | ||
| Taiwaniaflavone | 0.142 ± 0.026 | Noncompetitive |
a Values represent the average ± standard error in triplicate.
