Table 6.

Inhibitory effects of selamariscina A against six uridine 5′-diphosphoglucuronosyl transferase (UGT) isoforms.

UGT Enzyme	Substrate	IC50 (µM) a
1A1	SN-38 *	1.7 ± 0.5
1A3	Chenodeoxycholic acid	>50
1A4	Trifluoperazine	7.7 ± 1.9
1A6	N-Acetylserotonin	46.1 ± 11.7
1A9	Mycophenolic acid	40.4 ± 11.1
2B7	Naloxone	>50

* SN-38: 7-Ethyl-10-hydroxy camptothecin; ^a values represent the average ± standard error in triplicate.