Figure 2.

Activation energy diagram for the solubilization of a drug from a crystalline form (right) and from an ASD (left). (E_a is the energy required to disrupt crystalline lattice of a drug in a conventional formulation; E_c is the energy required to disrupt the glass solution of a drug in an ASD formulation, E_b is the energy required for solvent cavitation in the solubilization of a crystalline solid and E_d is the energy required for solvent cavitation in the case of ASD solubilization.).