Skip to main content
. 2020 Apr 14;12(4):357. doi: 10.3390/pharmaceutics12040357

Table 1.

Primary polymers/Oligomers selected for development of binary KSDs of abiraterone [35,45,46,47].

Polymer/Oligomer Hydroxy Propyl Methyl Cellulose (HPMC E3) Hydroxy Propyl Methyl Cellulose (HPMC E5) Polyvinyl Pyrrolidone (PVP 30) Polyvinyl Acetate Phthalate (PVAP) Hydroxy Propyl β Cyclodextrin (HPBCD)
Commercial Product used Methocel™ E3 Premium LV Methocel™ E5 Premium LV Kollidon® 30 Phthalavin® Kleptose® HPB
Chemistry Cellulose based Cellulose based Pyrrolidone based Phthalate based Glucose based
Monomer Structure graphic file with name pharmaceutics-12-00357-i001.jpg graphic file with name pharmaceutics-12-00357-i002.jpg graphic file with name pharmaceutics-12-00357-i003.jpg graphic file with name pharmaceutics-12-00357-i004.jpg
Architecture Long-chain Linear Polymer Long-chain Linear Polymer Long-chain Linear Polymer Long-chain Linear Polymer Short-chain Cyclic Oligomer
Molecular Weight ~20,000 ~28,700 ~50,000 ~60,700 1399
Viscosity 2.4–3.6 (mPa.s: 2% w/v in water at 20 °C) 4.0–6.0 (mPa.s: 2% w/v in water at 20 °C) 5.5–8.5 (mPa.s: 10% w/v in water at 20 °C) 7–11 (mPa.s: in water at 25 °C) <1.5 (mPa.s: 10% w/v in water at 25 °C)