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. 2020 Apr 14;12(4):357. doi: 10.3390/pharmaceutics12040357

Table 2.

Binary KSD compositions, processing parameters, and their corresponding appearance.

Lot No. Composition Batch Size (g) Processing Temperature (°C) Shear Stress (Rotational Speed (rpm)) * Processing Time (Seconds) Appearance
Drug (% wt) Primary Polymer/Oligomer (% wt)
1 Abiraterone (10) HPMC E3 (90) 10 160 4000, 5000, 6000 10 + 10 + 6.9 graphic file with name pharmaceutics-12-00357-i005.jpg
2 Abiraterone (10) HPMC E5 (90) 10 160 4000, 5000, 6000 10 + 10 + 7.1 graphic file with name pharmaceutics-12-00357-i006.jpg
3 Abiraterone (10) PVP K30 (90) 10 160 4000, 5000, 6000 10 + 10 + 3.7 graphic file with name pharmaceutics-12-00357-i007.jpg
4 Abiraterone (10) PVAP (90) 10 160 4000, 5000, 6000 10 + 10 +23 graphic file with name pharmaceutics-12-00357-i008.jpg
5 Abiraterone (10) HPBCD (90) 10 160 4000, 5000, 6000 10+10+6.3 graphic file with name pharmaceutics-12-00357-i009.jpg

* Each processing time number corresponds to the time spent on the corresponding shear stress stage (i.e., the rotation speed stage).