Table 4.
Ternary KSD composition, processing parameters, and appearance.
| Lot No. | Composition | Batch Size (g) | Processing Temperature (°C) | Shear Stress (Rotational Speed-Rpm) | * Processing Time (Seconds) | Appearance | ||
|---|---|---|---|---|---|---|---|---|
| API (% Wt) | Primary Cyclic Oligomer (% Wt) | Secondary Polymer (% Wt) | ||||||
| 6 | Abiraterone (10) | HPBCD (80) | HPMCAS 126 G (10) | 10 | 160 | 4000, 5000 | 10 + 3.6 |
|
| 7 | Abiraterone (10) | HPBCD (70) | HPMCAS 126 G (20) | 10 | 160 | 4000, 5000 | 10 + 6.3 |
|
| 8 | Abiraterone (10) | HPBCD (60) | HPMCAS 126 G (30) | 10 | 160 | 4000, 5000 | 10 + 5.2 |
|
| 9 | Abiraterone (10) | HPBCD (50) | HPMCAS 126 G (40) | 10 | 160 | 4000 | 9.6 |
|
* Each processing time number corresponds to the time spent on the corresponding shear stress stage (i.e., the rotation speed stage.