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Minimal inhibitory concentration (maximum dilution) of the eluates obtained over a period of 42 days from minocycline formulations (substance (minocycl.) and microspheres (microsph.) polymer-lipid complex extrudate (PLM-C)) and PLM-C without minocycline (vehicle) according to 1 µg of minocycline and simulating the flow of the gingival fluid against Streptococcus gordonii ATCC 10558 (A) and Porphyromonas gingivalis ATCC 33277 (B).
