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. 2020 Apr 5;12(4):326. doi: 10.3390/pharmaceutics12040326

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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BJ reduces the phosphorylation of mitogen-activated protein kinases (MAPKs) induced by 6-OHDA. 6-OHDA induces the phosphorylation of Erk1/2 and p38 MAPKs in SH-SY5Y cells that was prevented by the pre-treatment with BJ. A representative immunoblot is depicted (A). The densitometric analysis of three separate blots (mean ± S.E.M.) is showed (B). Protein levels are extrapolated as values detected in control cells, which are arbitrarily assigned as 1. °°° P < 0.001 vs. control; *, ** and *** P < 0.05, P < 0.01 and P < 0.001 vs. 6-OHDA-treated cells.