Table 2.
Comparison of dengue viral RNA levels (log10 genome copies/mL) in plasma of cynomolgus macaques, common marmosets, and tamarins during primary and secondary dengue virus infection.
| Type of Infection | Animal ID | Inoculated Virus | Dengue Viral RNA Copy Numbers (log10 Genome copies/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Days after Inoculation | |||||||||||
| 0 | 1 | 2 | 3 | 4 | 5 | 7 | 10 | 14 | |||
| Primary | (A) Cynomolgus macaques | ||||||||||
| Group 1 | |||||||||||
| CM1 | DENV1 01-27 | NT | NT | NT | 2.8 | NT | - | - | - | - | |
| CM2 | NT | NT | NT | - | NT | - | - | - | - | ||
| Group 2 | |||||||||||
| CM3 | DENV2 DHF0663 | NT | NT | NT | 6.5 | NT | - | - | - | - | |
| CM4 | NT | NT | NT | 3.1 | NT | - | - | - | - | ||
| CM5 | NT | NT | NT | 4.1 | NT | - | - | - | - | ||
| CM6 | NT | NT | NT | 7.2 | NT | - | - | - | - | ||
| Group 3 | |||||||||||
| CM7 | DENV3 DSS1403 | NT | NT | NT | 2.5 | NT | - | - | - | - | |
| CM8 | NT | NT | NT | 3.6 | NT | - | - | - | - | ||
| (B) Marmosets 1 | |||||||||||
| Group 4 | |||||||||||
| M1 | DENV1 02-17 | - | NT | NT | 5.6 | NT | 5.7 | - | - | - | |
| M2 | - | NT | 7.0 | NT | NT | 6.5 | 7.7 | 6.0 | - | ||
| Group 5 | |||||||||||
| M3 | DENV2 DHF0663 | - | NT | NT | 7.2 | NT | 5.0 | - | NT | - | |
| M4 | - | NT | NT | 7.5 | NT | 6.8 | 5.4 | NT | - | ||
| M5 | - | NT | 4.5 | NT | 6.0 | NT | 4.0 | NT | - | ||
| M6 | - | NT | 5.0 | NT | 6.3 | NT | 4.2 | NT | - | ||
| Group 6 | |||||||||||
| M7 | DENV3 DSS1403 | - | NT | NT | - | NT | 4.7 | - | - | - | |
| M8 | - | NT | 4.9 | NT | 5.6 | NT | - | NT | - | ||
| (C) Tamarins 1 | |||||||||||
| Group 7 | |||||||||||
| T1 | DENV2 DHF0663 | - | 6.4 | NT | 6.1 | NT | 4.2 | - | NT | NT | |
| T2 | - | 7.3 | NT | 7.5 | NT | 6.3 | 4.2 | NT | NT | ||
| Group 8 | |||||||||||
| T3 | DENV2 DHF0663 | - | 5.3 | NT | 6.2 | NT | NT | 4.5 | - | - | |
| T4 | - | 4.7 | NT | 4.6 | NT | NT | 5.4 | - | - | ||
| T5 | - | 5.3 | NT | 6.3 | NT | NT | 6.2 | - | - | ||
| Secondary | (D) Cynomolgus macaques | ||||||||||
| Group 9 | |||||||||||
| CM1 | DENV2 DHF0663 | NT | NT | NT | 6.2 | NT | - | - | - | - | |
| CM2 | NT | NT | NT | 6.2 | NT | - | - | - | - | ||
| Group 10 | |||||||||||
| CM3 | DENV3 DSS1403 | NT | NT | NT | 3.0 | NT | - | - | - | - | |
| CM4 | NT | NT | NT | 2.8 | NT | - | - | - | - | ||
| (E) Marmoset 2 | |||||||||||
| Group 11 | |||||||||||
| M9 | DENV2 DHF0663 | - | - | NT | 6.7 | NT | NT | 4.5 | NT | - | |
| M10 | - | - | NT | 6.2 | NT | NT | - | NT | - | ||
| M11 | - | - | NT | 6.4 | NT | NT | 3.9 | NT | - | ||
| Group 12 | |||||||||||
| M12 | DENV3 DSS1403 | - | - | 7.0 | NT | NT | 6.5 | 5.2 | 4.7 | - | |
| M13 | - | - | 7.5 | NT | NT | 7.7 | 6.0 | 4.2 | - | ||
(-) indicates below detection levels; NT indicates not tested or samples were not collected. 1 DENV genome levels in marmosets M1 to M8 and tamarins T3, T4, and T5 were previously reported [12,13]. 2 DENV genome levels in marmosets M9 to M13 were previously reported [20,21]. Cynomologous macaques (CM) were infected as previously reported [97,98].