Table 1.
Summary of the compendial characterization of nebulized surfactant generated by a customized eFlow Neos nebulizer through different types of nasal prongs of different sizes.
| Breath Simulation Experiments | Next Generation Impactor Experiments | ||||||
|---|---|---|---|---|---|---|---|
| Nasal Cannula Type | Delivered Dose (%) | Surfactant at Expiratory Filter (%) | Nebulization Time (min) | Calculated Delivered Dose (%) | Fine Particle Fraction (%) | MMAD (µm) | GSD |
| Dräger prongs (S) | 74.8 ± 0.7 | 19.2 ± 0.6 | 92 ± 36 | 91.1 ± 1.2 | 69.8 ± 4.6 | 2.81 ± 0.13 | 1.64 ± 0.10 |
| Dräger prongs (L) | 65.3 ± 0.6 | 23.5 ± 2.6 | 84.8 ± 11.7 | 86.3 ± 1.9 | 70.3 ± 4.1 | 2.81 ± 0.27 | 1.64 ± 0.11 |
| Fisher and Paykel 3520 | 62.9 ± 9.2 | 20.6 ± 1.1 | 80.9 ± 28.5 | 84.1 ± 7.1 | 62.8 ± 3.4 | 2.53 ± 0.07 | 1.53 ± 0.05 |
| Fisher and Paykel 5050 | 63.1 ± 1.2 | 23.3 ± 0.8 | 83.6 ± 25.4 | 86.3 ± 4.1 | 77.1 ± 8.7 | 2.76 ± 0.36 | 1.82 ± 0.46 |
| Argyle (XS) | 73.8 ± 3.9 | 20.7 ± 0.9 | 127.1 ± 43.59 | 88.0 ± 3.4 | 81.7 ± 0.8 | 2.79 ± 0.07 | 1.55 ± 0.04 |
| Argyle (L) | 71.7 ± 4.4 | 21.4 ± 0.2 | 85.1 ± 12.7 | 90.4 ± 2.9 | 80.9 ± 1.2 | 2.65 ± 0.02 | 1.53 ± 0.03 |
| Inspire (S) | 71.6 ± 2.1 | 21.6 ± 1.3 | 64.2 ± 11.58 | 90.4 ± 1 | 78.7 ± 5.4 | 2.75 ± 0.11 | 1.55 ± 0.06 |
| Inspire (L) | 65.5 ± 2.7 | 24.5 ± 2.5 | 112.8 ± 34.3 | 90.4 ± 1 | 74.2 ± 5.4 | 2.76 ± 0.12 | 1.58 ± 0.06 |
Mass Median Aerodynamic Diameter (MMAD); Geometric Standard Deviation (GSD).